Title
Spectroelectrochemical Determination of Isoprenaline in a Pharmaceutical Sample.
Abstract
UV/Vis absorption spectroelectrochemistry (SEC) is a multi-response technique that has been commonly used for the characterization of materials and the study of reaction mechanisms. However, it has been scarcely used for quantitative purposes. SEC allows us to obtain two analytical signals simultaneously, yielding a dual sensor in just one experiment. In the last years, our group has developed new devices useful for analysis. In this work, a SEC device in parallel configuration, based on optical fibers fixed on screen-printed electrodes, was used to determine isoprenaline in a commercial drug, using both, the electrochemical and the spectroscopic signals. In this commercial drug, isoprenaline is accompanied in solution by other compounds. Among them is sodium metabisulfite, an antioxidant that strongly interferes in the isoprenaline determination. A simple pretreatment of the drug sample by bubbling wet-air allows us to avoid the interference of metabisulfite. Here, we demonstrate again the capabilities of UV/Vis absorption SEC as double sensor for analysis and we propose a simple pretreatment to remove interfering compounds.
Year
DOI
Venue
2020
10.3390/s20185179
SENSORS
Keywords
DocType
Volume
spectroelectrochemistry,electrochemistry,UV,Vis absorption,drug analysis,isoproterenol,metabisulfite
Journal
20
Issue
ISSN
Citations 
18
1424-8220
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Fabiola Olmo100.34
Jesus Garoz-Ruiz200.68
Julia Carazo300.34
Alvaro Colina401.01
Aránzazu Heras501.01