Paper Info
Title
Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait.
Abstract
Piao chicken, a rare Chinese native poultry breed, lacks primary tail structures, such as pygostyle, caudal vertebra, uropygial gland, and tail feathers. So far, the molecular mechanisms underlying tail absence in this breed remain unclear. In this study, we comprehensively employed comparative transcriptomic and genomic analyses to unravel potential genetic underpinnings of rumplessness in Piao chicken. Our results reveal many biological factors involved in tail development and several genomic regions under strong positive selection in this breed. These regions contain candidate genes associated with rumplessness, including Irx4, Il18, Hspb2, and Cryab. Retrieval of quantitative trait loci (QTL) and gene functions implies that rumplessness might be consciously or unconsciously selected along with the high-yield traits in Piao chicken. We hypothesize that strong selection pressures on regulatory elements might lead to changes in gene activity in mesenchymal stem cells of the tail bud. The ectopic activity could eventually result in tail truncation by impeding differentiation and proliferation of the stem cells. Our study provides fundamental insights into early initiation and genetic basis of the rumpless phenotype in Piao chicken.
Year
DOI
Venue
2021
10.1016/j.gpb.2020.06.019
Genomics, Proteomics & Bioinformatics
Keywords
DocType
Volume
Artificial selection,Comparative transcriptomics,Population genomics,Rumplessness,Vertebra development
Journal
19
Issue
ISSN
Citations 
5
1672-0229
0
PageRank 
References 
Authors
0.34
0
10
Name
Order
Citations
PageRank
Yun-Mei Wang100.34
Saber Khederzadeh200.34
Shi-Rong Li300.34
Newton Otieno Otecko400.34
David M Irwin532.56
Mukesh Thakur600.34
Xiao-Die Ren700.34
Ming-Shan Wang800.34
Dongdong Wu900.68
Ya-Ping Zhang10114.66