Paper Info
Title
Lookup Table-Based Fast Reliability-Aware Sample Preparation Using Digital Microfluidic Biochips
Abstract
Reliability of the prepared fluidic samples is a major concern for automated sample preparation using microfluidic biochips, where induced errors in the resultant concentration values severely affect the assay outcome. However, the existing design automation techniques have not thoroughly considered the reliability model to reduce the induced concentration errors during sample preparation. This article proposes a fast reliability-aware sample preparation (RASP) method for determining the optimized sequence of mixing steps (mixing process) with the enhanced reliability. In RASP, a probabilistic concentration prediction model is proposed for analyzing the reliability of a given mixing process. Based on this probabilistic model, a lookup table construction algorithm along with the table query method is proposed to obtain the optimized mixing process. The simulation results show that for any user-specified target concentration, RASP can effectively determine the optimized mixing process, which generates the droplets with target concentration within the error tolerance of 0.1%. Compared with the state-of-the-art sample preparation algorithm, RASP improves the reliability-related accuracy by 91.4% on average via 2048 testcases.
Year
DOI
Venue
2020
10.1109/TCAD.2019.2948907
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Keywords
DocType
Volume
Digital microfluidic (DMF) biochips,lookup table,reliability,sample preparation
Journal
39
Issue
ISSN
Citations 
10
0278-0070
0
PageRank 
References 
Authors
0.34
0
5
Name
Order
Citations
PageRank
Lingxuan Shao140.75
Wentai Li200.34
Tsung-Yi Ho35921.63
Sudip Roy430929.71
Hailong Yao526739.56