Name
Title | ||
|---|---|---|
Digger: Exploring The Functional Role Of Alternative Splicing In Protein Interactions |
Abstract | ||
|---|---|---|
Alternative splicing plays a major role in regulating the functional repertoire of the proteome. However, isoform-specific effects to protein-protein interactions (PPIs) are usually overlooked, making it impossible to judge the functional role of individual exons on a systems biology level. We overcome this barrier by integrating protein-protein interactions, domain-domain interactions and residue-level interactions information to lift exon expression analysis to a network level. Our user-friendly database DIGGER is available at https://exbio.wzw.tum.de/digger and allows users to seamlessly switch between isoform and exon-centric views of the interactome and to extract sub-networks of relevant isoforms, making it an essential resource for studying mechanistic consequences of alternative splicing. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1093/nar/gkaa768 | NUCLEIC ACIDS RESEARCH |
DocType | Volume | Issue |
Journal | 49 | D1 |
ISSN | Citations | PageRank |
0305-1048 | 0 | 0.34 |
References | Authors | |
0 | 8 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Zakaria Louadi | 1 | 0 | 0.34 |
| Kevin Yuan | 2 | 0 | 0.34 |
| Alexander Gress | 3 | 0 | 0.34 |
| Olga Tsoy | 4 | 0 | 0.34 |
| Olga V. Kalinina | 5 | 3 | 1.43 |
| Jan Baumbach | 6 | 148 | 22.11 |
| Tim Kacprowski | 7 | 10 | 2.28 |
| Markus List | 8 | 18 | 6.77 |