Title
Enhance Categorisation Of Multilevel High-Sensitivity Cardiovascular Biomarkers From Lateral Flow Immunoassay Images Via Neural Networks And Dynamic Time Warping
Abstract
Lateral Flow Immunoassays (LFA) are low cost, rapid and highly efficacious Point-of-Care devices. Traditional LFA testing faces challenges to detect high-sensitivity biomarkers due to low sensitivity. Unlike most approaches based on averaging image intensity from a region-of-interest (ROI), this paper presents a novel system that considers each row of an LFA image as a time series signal and, consequently, does not require the detection of ROI. Long Short-Term Memory (LSTM) networks are used to classify LFA data obtained from multilevel high-sensitivity cardiovascular biomarkers. Dynamic Time Warping (DTW) was incorporated with LSTM to align the LFA data from different concentration levels to a common reference before feeding the distance maps into an LSTM network. The LSTM network outperforms other classifiers with or without DTW. Furthermore, performance of all classifiers is improved after incorporating DTW. The positive outcomes suggest the potential of the proposed methods for early risk assessment of cardiovascular diseases.
Year
DOI
Venue
2020
10.1109/ICIP40778.2020.9190827
2020 IEEE International Conference on Image Processing (ICIP)
Keywords
DocType
ISSN
Time series analysis,Testing,Biomarkers,Logic gates,Immune system,Support vector machines
Conference
1522-4880
ISBN
Citations 
PageRank 
978-1-7281-6395-6
0
0.34
References 
Authors
0
8
Name
Order
Citations
PageRank
Min Jing100.34
Brian Mac Namee200.34
Donal Mc Laughlin300.34
David Steele400.34
Sara Mc Namee500.34
Patrick Cullen600.34
Dewar D. Finlay78722.60
McLaughlin, J.8411.37