Title
Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients
Abstract
Vagal Nerve Stimulation (VNS) is an option in the treatment of drug-resistant epilepsy. However, approximately a quarter of VNS subjects does not respond to the therapy. In this retrospective study, we introduce heart-rate features to distinguish VNS responders and non-responders. Standard pre-implantation measurements of 66 patients were segmented in relation to specific stimuli (open/close eyes, photic stimulation, hyperventilation, and rests between). Median interbeat intervals were found for each segment and normalized (NMRR). Five NMRRs were significant; the strongest feature achieved significance with p=0.013 and AUC=0.66. Low mutual correlation and independence on EEG signals mean that presented features could be considered as an addition for models predicting VNS response using EEG.
Year
DOI
Venue
2020
10.1109/EMBC44109.2020.9176326
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
Keywords
DocType
Volume
Electroencephalography,Epilepsy,Heart Rate,Humans,Retrospective Studies,Vagus Nerve Stimulation
Conference
2020
ISSN
ISBN
Citations 
2375-7477
978-1-7281-1991-5
0
PageRank 
References 
Authors
0.34
0
7
Name
Order
Citations
PageRank
Plesinger, F.138.70
Halamek, J.239.72
Jan Chládek301.01
Pavel Jurák4512.45
I Dolezalova500.34
J Chrastina600.34
Milan Brázdil7234.78