Paper Info
Title
Temporally Interfering Tms: Focal And Dynamic Stimulation Location
Abstract
In this study, we present a temporal interference (TI) concept to achieve focal and steerable stimulation in the targeted brain area through transcranial magnetic stimulation (TMS). This method works by inducing two high-frequency electric fields with a slight frequency difference via two independent coils. The intrinsic nonlinear nature of the nerve membrane, which acts as a low-pass filter, does not allow the nerve to engage at high frequencies. Instead, neurons at the intersection of two electric fields can follow the frequency difference of the two fields. For 3D MRI-derived head models, the finite element method is used to compute the electric field induced by the time-varying magnetic field along with the electric field penetration depth and the activated volume for the specific coil parameters. A deeper stimulation with an acceptable spatial spread can be obtained by controlling the intersection of the fields by finding the optimal position and orientation of the two coils. Moreover, by changing the voltage ratio of the coils, and not their mechanical orientation, the intended area can be dynamically driven. The computational results show that the TI technique is an efficient approach to resolve the electric field depth-focality trade-off, which can be a reasonable alternative to complex coil designs. The system proposed in this paper shows a great promise for a more dynamic and focused magnetic stimulation.
Year
DOI
Venue
2020
10.1109/EMBC44109.2020.9176249
42ND ANNUAL INTERNATIONAL CONFERENCES OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY: ENABLING INNOVATIVE TECHNOLOGIES FOR GLOBAL HEALTHCARE EMBC'20
Keywords
DocType
Volume
Transcranial magnetic stimulation, Temporal interference, TMS focality, deep TMS, TI-TMS, TMS coil design
Conference
2020
ISSN
Citations 
PageRank 
1557-170X
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Majid Memarian Sorkhabi100.68
Karen Wendt211.45
Timothy Denison311.45