Title
A NOVEL DERIVATION OF RIGOROUS MACROSCOPIC LIMITS FROM A MICRO-MESO DESCRIPTION OF SIGNAL-TRIGGERED CELL MIGRATION IN FIBROUS ENVIRONMENTS
Abstract
In this work we upscale a prototypical kinetic equation model for a cell population moving in a fibrous environment with a chemo-or haptotactic signal influencing both the direction and the magnitude of the cell velocity. The presented approach to scaling does not rely on orthogonality and treats parabolic and hyperbolic scalings in a unified manner. It is shown that the steps of the formal limit procedures are mirrored by rigorous operations with finite measures provided that the measure-valued position-direction fiber distribution enjoys some spatial continuity.
Year
DOI
Venue
2022
10.1137/20M1365442
SIAM JOURNAL ON APPLIED MATHEMATICS
Keywords
DocType
Volume
kinetic transport equations, hyperbolic, parabolic scaling, cell movement, reaction-diffusion-taxis equations, measure-valued solutions, multiscale modeling
Journal
82
Issue
ISSN
Citations 
1
0036-1399
0
PageRank 
References 
Authors
0.34
0
2
Name
Order
Citations
PageRank
Anna Zhigun100.34
Christina Surulescu271.57