Paper Info
Title
Regional Disconnection In Alzheimer Dementia And Amyloid-Positive Mild Cognitive Impairment: Association Between Eeg Functional Connectivity And Brain Glucose Metabolism
Abstract
Introduction: The disconnection hypothesis of Alzheimer's disease (AD) is supported by growing neuroimaging and neurophysiological evidence of altered brain functional connectivity in cognitively impaired individuals. Brain functional modalities such as [F-18]fluorodeoxyglucose positron-emission tomography ([F-18]FDG-PET) and electroencephalography (EEG) measure different aspects of synaptic functioning, and can contribute to understanding brain connectivity disruptions in AD.Aim: This study investigated the relationship between cortical glucose metabolism and topographical EEG measures of brain functional connectivity in subjects along AD continuum.Methods: Patients diagnosed with mild cognitive impairment (MCI) and AD (n = 67), and stratified into amyloid-positive (n = 32) and negative (n = 10) groups according to cerebrospinal fluid A beta 42/40 ratio, were assessed with [F-18]FDG-PET and resting-state EEG recordings. EEG-based neuroimaging analysis involved standardized low-resolution electromagnetic tomography (sLORETA), which estimates functional connectivity from cortical sources of electrical activity in a 3D head model.Results: Glucose hypometabolism in temporoparietal lobes was significantly associated with altered EEG functional connectivity of the same regions of interest in clinically diagnosed MCI and AD patients and in patients with biomarker-verified AD pathology. The correlative pattern of disrupted connectivity in temporoparietal lobes, as detected by EEG sLORETA analysis, included decreased instantaneous linear connectivity in fast frequencies and increased lagged linear connectivity in slow frequencies in relation to the activity of remaining cortex.Conclusions: Topographical EEG measures of functional connectivity detect regional dysfunction of AD-vulnerable brain areas as evidenced by association and spatial overlap with the cortical glucose hypometabolism in MCI and AD patients.
Year
DOI
Venue
2020
10.1089/brain.2020.0785
BRAIN CONNECTIVITY
Keywords
DocType
Volume
Alzheimer's disease, electroencephalography, [F-18]fluorodeoxyglucose-PET, functional connectivity, standardized low-resolution electromagnetic tomography (sLORETA)
Journal
10
Issue
ISSN
Citations 
10
2158-0014
0
PageRank 
References 
Authors
0.34
0
8
Name
Order
Citations
PageRank
Una Smailovic100.34
Thomas Koenig215112.57
Irina Savitcheva300.34
Konstantinos Chiotis400.34
A Nordberg571.33
Kaj Blennow600.34
Bengt Winblad741.20
Vesna Jelic800.68