Name
Title | ||
|---|---|---|
Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept |
Abstract | ||
|---|---|---|
•We investigate 18F-flutemetamol pharmacokinetics in probable CAA using PETMR.•We develop a model-based input function (mIF) and assess perfusion and tracer uptake.•We compare measurements from 30 min, against 120 min and SUVR PET-MR.•mIF 1-TC detected impaired perfusion and amyloid load in CAA from both time frames.•Perfusion deficits and amyloid burden were congruent in cases with probable CAA. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1016/j.neuroimage.2020.117482 | NeuroImage |
Keywords | DocType | Volume |
Positron emission tomography,Magnetic resonance imaging,Pharmacokinetic modelling,Perfusion,18F-flutemetamol uptake,Cerebral amyloid angiopathy | Journal | 225 |
ISSN | Citations | PageRank |
1053-8119 | 0 | 0.34 |
References | Authors | |
3 | 9 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| G. Papanastasiou | 1 | 32 | 4.44 |
| Mark A Rodrigues | 2 | 0 | 0.34 |
| Chengjia Wang | 3 | 0 | 0.34 |
| Kerstin Heurling | 4 | 0 | 0.34 |
| Christophe Lucatelli | 5 | 0 | 0.34 |
| Rustam Al-Shahi Salman | 6 | 0 | 0.34 |
| Joanna M. Wardlaw | 7 | 108 | 17.52 |
| Edwin J. R. van Beek | 8 | 0 | 0.68 |
| Gerard Thompson | 9 | 0 | 0.34 |