Title
Toward an Automated HPC Pipeline for Processing Large Scale Electron Microscopy Data
Abstract
We present a fully modular and scalable software pipeline for processing electron microscope (EM) images of brain slices into 3D visualization of individual neurons and demonstrate an end-to-end segmentation of a large EM volume using a supercomputer. Our pipeline scales multiple packages used by the EM community with minimal changes to the original source codes. We tested each step of the pipeline individually, on a workstation, a cluster, and a supercomputer. Furthermore, we can compose workflows from these operations using a Balsam database that can be triggered during the data acquisition or with the use of different front ends and control the granularity of the pipeline execution. We describe the implementation of our pipeline and modifications required to integrate and scale up existing codes. The modular nature of our environment enables diverse research groups to contribute to the pipeline without disrupting the workflow, i.e. new individual codes can be easily integrated for each step on the pipeline.
Year
DOI
Venue
2020
10.1109/XLOOP51963.2020.00008
2020 IEEE/ACM 2nd Annual Workshop on Extreme-scale Experiment-in-the-Loop Computing (XLOOP)
Keywords
DocType
ISBN
Connectome,Workflow,Automation,Supercomputing
Conference
978-1-6654-2283-3
Citations 
PageRank 
References 
0
0.34
4
Authors
8
Name
Order
Citations
PageRank
Rafael Vescovi111.03
Hanyu Li265.58
Jeffery Kinnison311.04
Murat Keçeli482.59
Misha Salim500.34
Narayanan Kasthuri6627.11
Thomas D. Uram79511.29
Nicola J. Ferrier818124.79