Paper Info
Title
Each Patient Is A Research Biorepository: Informatics-Enabled Research On Surplus Clinical Specimens Via The Living Biobank
Abstract
The ability to analyze human specimens is the pillar of modern-day translational research. To enhance the research availability of relevant clinical specimens, we developed the Living BioBank (LBB) solution, which allows for just-in-time capture and delivery of phenotyped surplus laboratory medicine specimens. The LBB is a system-of-systems integrating research feasibility databases in i2b2, a real-time clinical data warehouse, and an informatics system for institutional research services management (SPARC). LBB delivers deidentified clinical data and laboratory specimens. We further present an extension to our solution, the Living mu Biome Bank, that allows the user to request and receive phenotyped specimen microbiome data. We discuss the details of the implementation of the LBB system and the necessary regulatory oversight for this solution. The conducted institutional focus group of translational investigators indicates an overall positive sentiment towards potential scientific results generated with the use of LBB. Reference implementation of LBB is available at https://LivingBioBank.musc.edu.
Year
DOI
Venue
2021
10.1093/jamia/ocaa236
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
Keywords
DocType
Volume
just-in-time biobanking, phenotyped specimens, phenotyped specimen data, translational research services
Journal
28
Issue
ISSN
Citations 
1
1067-5027
0
PageRank 
References 
Authors
0.34
0
10
Name
Order
Citations
PageRank
Alexander V. Alekseyenko1379.10
Bashir Hamidi200.34
Trevor D Faith300.34
Keith Crandall49714.34
Jennifer G Powers500.34
Christopher L Metts600.34
James E Madory700.34
Steven L Carroll800.34
Jihad S. Obeid942.11
Leslie A Lenert1001.35