Paper Info
Title
Towards linking diffusion MRI based macro- and microstructure measures with cortico-cortical transmission in brain tumor patients
Abstract
We aimed to link macro- and microstructure measures of brain white matter obtained from diffusion MRI with effective connectivity measures based on a propagation of cortico-cortical evoked potentials induced with intrasurgical direct electrical stimulation. For this, we compared streamline lengths and log-transformed ratios of streamlines computed from presurgical diffusion-weighted images, and the delays and amplitudes of N1 peaks recorded intrasurgically with electrocorticography electrodes in a pilot study of 9 brain tumor patients. Our results showed positive correlation between these two modalities in the vicinity of the stimulation sites (Pearson coefficient 0.54±0.13 for N1 delays, and 0.47±0.23 for N1 amplitudes), which could correspond to the neural propagation via U-fibers. In addition, we reached high sensitivities (0.78±0.07) and very high specificities (0.93±0.03) in a binary variant of our comparison. Finally, we used the structural connectivity measures to predict the effective connectivity using a multiple linear regression model, and showed a significant role of brain microstructure-related indices in this relation.
Year
DOI
Venue
2021
10.1016/j.neuroimage.2020.117567
NeuroImage
Keywords
DocType
Volume
Structural connectivity,Brain white matter microstructure,Effective connectivity,Cortico-cortical evoked potentials,Direct electrical stimulation,Tractography
Journal
226
ISSN
Citations 
PageRank 
1053-8119
0
0.34
References 
Authors
12
9
Name
Order
Citations
PageRank
Patryk Filipiak100.34
Fabien Almairac200.34
Théodore Papadopoulo332426.84
Denys Fontaine400.34
Lydiane Mondot500.34
Stéphane Chanalet600.34
Rachid Deriche74903633.65
maureen clerc812816.39
Demian Wassermann97611.03