Evlncrnas 2.0: An Updated Database Of Manually Curated Functional Long Non-Coding Rnas Validated By Low-Throughput Experiments

Paper Info

Title
Evlncrnas 2.0: An Updated Database Of Manually Curated Functional Long Non-Coding Rnas Validated By Low-Throughput Experiments

Abstract
Long non-coding RNAs (lncRNAs) play important functional roles in many diverse biological processes. However, not all expressed lncRNAs are functional. Thus, it is necessary to manually collect all experimentally validated functional lncRNAs (EVlncRNA) with their sequences, structures, and functions annotated in a central database. The first release of such a database (EVLncRNAs) was made using the literature prior to 1 May 2016. Since then (till 15 May 2020), 19 245 articles related to lncRNAs have been published. In EVLncRNAs 2.0, these articles were manually examined for a major expansion of the data collected. Specifically, the number of annotated EVlncRNAs, associated diseases, lncRNA-disease associations, and interaction records were increased by 260%, 320%, 484% and 537%, respectively. Moreover, the database has added several new categories: 8 lncRNA structures, 33 exosomal lncRNAs, 188 circular RNAs, and 1079 drug-resistant, chemoresistant, and stress-resistant lncRNAs. All records have checked against known retraction and fake articles. This release also comes with a highly interactive visual interaction network that facilitates users to track the underlying relations among lncRNAs, miRNAs, proteins, genes and other functional elements. Furthermore, it provides links to four new bioinformatics tools with improved data browsing and searching functionality. EVLncRNAs 2.0 is freely available at https:// www.sdklab-biophysics-dzu.net/EVLncRNAs2/.

Authors (22 rows)

Cited by (0 rows)

References (22 rows)

Name	Order	Citations	PageRank
Bailing Zhou	1	6	1.87
Baohua Ji	2	0	0.34
Kui Liu	3	0	0.34
Guodong Hu	4	2	1.72
Fei Wang	5	241	51.35
Qingshuai Chen	6	0	0.34
Ru Yu	7	0	0.34
Pingping Huang	8	0	0.34
Jing Ren	9	0	0.34
Chengang Guo	10	2	0.71
Huiying Zhao	11	2	0.71
Hongmei Zhang	12	0	0.34
Dongbo Zhao	13	0	0.34
Zhiwei Li	14	1315	107.73
Qiangcheng Zeng	15	0	0.34
Jia-Feng Yu	16	8	2.04
Yunqiang Bian	17	0	0.34
Zanxia Cao	18	2	0.71
Shicai Xu	19	0	0.34
Yuedong Yang	20	196	23.47
Yaoqi Zhou	21	14	1.29
Jihua Wang	22	0	0.34