Paper Info
Title
Methhc 2.0: Information Repository Of Dna Methylation And Gene Expression In Human Cancer
Abstract
DNA methylation is an important epigenetic regulator in gene expression and has several roles in cancer and disease progression. MethHC version 2.0 (MethHC 2.0) is an integrated and web-based resource focusing on the aberrant methylomes of human diseases, specifically cancer. This paper presents an updated implementation of MethHC 2.0 by incorporating additional DNA methylomes and transcriptomes from several public repositories, including 33 human cancers, over 50 118 microarray and RNA sequencing data from TCGA and GEO, and accumulating up to 3586 manually curated data from >7000 collected published literature with experimental evidence. MethHC 2.0 has also been equipped with enhanced data annotation functionality and a user-friendly web interface for data presentation, search, and visualization. Provided features include clinical-pathological data, mutation and copy number variation, multiplicity of information (gene regions, enhancer regions, and CGI regions), and circulating tumor DNA methylation profiles, available for research such as biomarker panel design, cancer comparison, diagnosis, prognosis, therapy study and identifying potential epigenetic biomarkers. MethHC 2.0 is now available at http://awi.cuhk.edu.cn/similar to MethHC.
Year
DOI
Venue
2021
10.1093/nar/gkaa1104
NUCLEIC ACIDS RESEARCH
DocType
Volume
Issue
Journal
49
D1
ISSN
Citations 
PageRank 
0305-1048
0
0.34
References 
Authors
0
21
Name
Order
Citations
PageRank
Hsi-Yuan Huang141.08
Jing Li234553.26
Yun Tang340.74
Yi-Xian Huang400.34
Yi-Gang Chen540.74
Yue-Yang Xie640.74
Zhe-Yuan Zhou700.34
Xin-Yi Chen800.34
Si-Yuan Ding940.74
Meng-Fan Luo1040.74
Chen-Nan Jin1140.74
Le-Shan Zhao1200.34
Jia-Tong Xu1340.74
Qing Zhou1445449.57
Yang-Chi-Dung Lin1541.08
Hsiao-Chin Hong1641.08
Hua-Li Zuo1700.34
Si-Yao Hu1800.34
Pei-Yi Xu1900.34
Xin Li2021936.02
Hsien-Da Huang2183563.83