Title
Distributed Contextualization of Biomedical Data: A Case Study in Precision Medicine
Abstract
An important aspect of precision medicine consists in patient-centered contextualization analyses that are used as part of biomedical interactive tools. Such analyses often harness data of large populations of patients from different research centers and can often benefit from a distributed implementation. However, performance and the security and privacy concerns of sharing sensitive biomedical data can become a major issue. We have investigated these issues in the context of a kidney transplanted patient contextualization project: the Kidney Transplantation Application (KITAPP). In this paper, we present a motivation for distributed implementations in this context, notably for computing percentiles for contextualization. We present a corresponding system architecture, motivate privacy and performance issues, and present a novel distributed implementation that is evaluated in a realistic multi-site setting.
Year
DOI
Venue
2020
10.1109/AICCSA50499.2020.9316502
2020 IEEE/ACS 17th International Conference on Computer Systems and Applications (AICCSA)
Keywords
DocType
ISSN
contextualization,precision medicine,kidney transplantation,distributed analysis,privacy,percentile
Conference
2161-5322
ISBN
Citations 
PageRank 
978-1-7281-8578-1
0
0.34
References 
Authors
0
5
Name
Order
Citations
PageRank
Sirine Sayadi100.34
Estelle Geffard200.34
Mario Südholt300.34
Nicolas Vince400.68
Pierre-Antoine Gourraud521.80