Name
Title | ||
|---|---|---|
Computerized spermatogenesis staging (CSS) of mouse testis sections via quantitative histomorphological analysis |
Abstract | ||
|---|---|---|
•This is the first report on the development of computerized staging of spermatogenesis process in mouse H&E stained testis sections based on quantitative image analysis.•Types of spermatogenic cells and multi-concentric-layers segmentation models were developed to identify spermatogenic cells and multi-concentric-layers in seminiferous tubules.•New histomorphological features were developed for discriminating tubules in stages VI-VIII.•Derivative-of-Gaussian filter is leveraged to extract elongated spermatids orientation entropy, which is the primary feature for discriminating tubules in stages VI-VIII.•The significant histomorphological features chosen by CSS system were spermatognial textures, elongated spermatids orientation and spermatids textures, which are the primary features of staging-identifying criteria by histologists in discriminating stages VI, VII-mVIII, and late VIII. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1016/j.media.2020.101835 | Medical Image Analysis |
Keywords | DocType | Volume |
Mouse testis histology,Sperm development,Mouse testicular section images,Seminiferous tubules,Computerized staging of spermatogenesis,Spermatogenic cell segmentation,Deep learning | Journal | 70 |
ISSN | Citations | PageRank |
1361-8415 | 0 | 0.34 |
References | Authors | |
0 | 9 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Jun Xu | 1 | 31 | 3.33 |
| Haoda Lu | 2 | 0 | 2.03 |
| Haixin Li | 3 | 0 | 0.34 |
| Chaoyang Yan | 4 | 0 | 1.01 |
| Xiangxue Wang | 5 | 1 | 3.77 |
| Min Zang | 6 | 0 | 0.34 |
| Dirk G. de Rooij | 7 | 0 | 0.34 |
| Anant Madabhushi | 8 | 1736 | 139.21 |
| Eugene Yujun Xu | 9 | 0 | 0.34 |