Title
Multi-objective optimization of a nonlinear switched time-delay system in microbial fed-batch process
Abstract
•Considering uncoupled, free terminal time, dha regulator, intracellular and extracellular environment, a nonlinear switched time-delay system model is established involving four time-delays and four switching modes for fed-batch fermentation of glycerol to 1,3-PD.•For determining optimal time-delays, a robustness index is given based expectation and variance.•The gradient formulas of the indices and constraints with respect to time-delays, terminal time and feeding rates are given with their proofs.•Considering the three-objective optimization model, we formulate an algorithm and obtain the valuable Pareto solutions by large scale calculation.
Year
DOI
Venue
2020
10.1016/j.jfranklin.2020.07.036
Journal of the Franklin Institute
DocType
Volume
Issue
Journal
357
17
ISSN
Citations 
PageRank 
0016-0032
0
0.34
References 
Authors
0
3
Name
Order
Citations
PageRank
Xiaohua Gao100.34
Jingang Zhai262.12
Enmin Feng311124.41