Paper Info
Title
The Role of Criticality of Gene Regulatory Networks in Morphogenesis
Abstract
Gene regulatory network (GRN)-based morphogenetic models have recently gained an increasing attention. However, the relationship between microscopic properties of intracellular GRNs and macroscopic properties of morphogenetic systems has not been fully understood yet. Here, we propose a theoretical morphogenetic model representing an aggregation of cells, and reveal the relationship between criticality of GRNs and morphogenetic pattern formation. In our model, the positions of the cells are determined by spring-mass-damper kinetics. Each cell has an identical Kauffman's NK random Boolean network (RBN) as its GRN. We varied the properties of GRNs from ordered, through critical, to chaotic by adjusting node in-degree K. We randomly assigned four cell fates to the attractors of RBNs for cellular behaviors. By comparing diverse morphologies generated in our morphogenetic systems, we investigated what the role of the criticality of GRNs is in forming morphologies. We found that nontrivial spatial patterns were generated most frequently when GRNs were at criticality. Our finding indicates that the criticality of GRNs facilitates the formation of nontrivial morphologies in GRN-based morphogenetic systems.
Year
DOI
Venue
2020
10.1109/TCDS.2018.2876090
IEEE Transactions on Cognitive and Developmental Systems
Keywords
DocType
Volume
Cell fate,criticality,gene regulatory network (GRN),morphogenetic pattern,morphogenetic system,random Boolean network (RBN)
Journal
12
Issue
ISSN
Citations 
3
2379-8920
0
PageRank 
References 
Authors
0.34
0
2
Name
Order
Citations
PageRank
Hyo-Bin Kim162.50
Hiroki Sayama231949.14