Paper Info
Title
Extracting Explainable Assessments Of Alzheimer'S Disease Via Machine Learning On Brain Mri Imaging Data
Abstract
A plethora of machine learning and deep learning methods are used for the assessment of Alzheimer's Disease (AD) from brain structural changes as seen in Magnetic Resonance Imaging (MRI) with highly satisfactory results. However, these models are black-box and lack an explicit declarative knowledge representation and thus there is a difficulty in generating the underlying explanatory imaging structures. The objective of this study was to investigate the usefulness of rule extraction in the assessment of AD using decision trees (DT) and random forests (RF) algorithms and integrating the extracted rules within an argumentation- based reasoning framework in order to make the results easy to interpret and explain. The DT and RF algorithms were applied on brain MRI images acquired from normal controls (NC) and AD subjects. The KNIME analytics platform was used to compute the DT and the R project was used for the RF. The argumentation model implemented in the Gorgias framework achieved an average accuracy of 91%, exhibiting improved results compared to the models of DT and RF. The overall performance of all models in this study is in agreement with other studies. In addition, the explanations given by our approach for the various possible predictions provide a more useful and complete assessment of the state of the patient/case at hand. This study demonstrated the usefulness of rule extraction in the assessment of AD based on MRI features and the positive results of the use of the argumentation based symbolic reasoning for composing and interpreting the ML results.
Year
DOI
Venue
2020
10.1109/BIBE50027.2020.00175
2020 IEEE 20TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOENGINEERING (BIBE 2020)
Keywords
DocType
ISSN
Alzheimer's disease, decision trees, random forests, quantitative MRI, Explainable AI, Argumentation
Conference
2471-7819
Citations 
PageRank 
References 
0
0.34
0
Authors
6
Name
Order
Citations
PageRank
Kleo G. Achilleos100.34
Stephanos Leandrou200.68
Nicoletta Prentzas300.68
P A Kyriacou42016.60
Antonis C. Kakas500.68
Constantinos S. Pattichis638243.89