Name
Title | ||
|---|---|---|
High-Speed High-Resolution Laser Diode-Based Photoacoustic Microscopy For In Vivo Microvasculature Imaging |
Abstract | ||
|---|---|---|
Laser diodes (LDs) have been considered as cost-effective and compact excitation sources to overcome the requirement of costly and bulky pulsed laser sources that are commonly used in photoacoustic microscopy (PAM). However, the spatial resolution and/or imaging speed of previously reported LD-based PAM systems have not been optimized simultaneously. In this paper, we developed a high-speed and high-resolution LD-based PAM system using a continuous wave LD, operating at a pulsed mode, with a repetition rate of 30 kHz, as an excitation source. A hybrid scanning mechanism that synchronizes a one-dimensional galvanometer mirror and a two-dimensional motorized stage is applied to achieve a fast imaging capability without signal averaging due to the high signal-to-noise ratio. By optimizing the optical system, a high lateral resolution of 4.8 mu m has been achieved. In vivo microvasculature imaging of a mouse ear has been demonstrated to show the high performance of our LD-based PAM system. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1186/s42492-020-00067-5 | VISUAL COMPUTING FOR INDUSTRY BIOMEDICINE AND ART |
Keywords | DocType | Volume |
Photoacoustic microscopy, Laser diode, In vivo imaging, Microvasculature imaging | Journal | 4 |
Issue | ISSN | Citations |
1 | 2524-4442 | 0 |
PageRank | References | Authors |
0.34 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Xiufeng Li | 1 | 1 | 0.72 |
| Victor T C Tsang | 2 | 0 | 0.34 |
| Kang Lei | 3 | 21 | 6.66 |
| Y Zhang | 4 | 31 | 7.34 |
| Terence T W Wong | 5 | 0 | 0.34 |