Title
CONTRAST-ENHANCED BRAIN MRI SYNTHESIS WITH DEEP LEARNING: KEY INPUT MODALITIES AND ASYMPTOTIC PERFORMANCE
Abstract
Contrast-enhanced medical images offer vital insights for the accurate diagnosis, characterization and treatment of tumors, and are routinely used worldwide. Acquiring such images requires to inject the patient intravenously with a gadolinium-based contrast agent (GBCA). Although GBCAs are considered safe, recent concerns about their accumulation in the body tilted the medical consensus towards a more parsimonious usage. Focusing on the case of brain magnetic resonance imaging, this paper proposes a deep learning method that synthesizes virtual contrast-enhanced T1 images as if they had been acquired after the injection of a standard 0.100 mmol/kg dose of GBCA, taking as inputs complementary imaging modalities obtained either after a reduced injection at 0.025 mmol/kg or without any GBCA involved. The method achieves a competitive structural similarity index of 94.2%. Its asymptotic performance is estimated, and the most important input modalities are identified.
Year
DOI
Venue
2021
10.1109/ISBI48211.2021.9434029
2021 IEEE 18TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI)
Keywords
DocType
ISSN
Brain MRI, gadolinium-based contrast agents (GBCA), low-dose imaging, virtual enhancement
Conference
1945-7928
Citations 
PageRank 
References 
0
0.34
0
Authors
10