Title | ||
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An Optical and Temperature Assisted CMOS ISFET Sensor Array for Robust E. Coli Detection |
Abstract | ||
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Both bacterial viability and concentration are significant metrics for bacterial detection. Existing miniaturized and cost-effective single-mode sensor, pH or optical, can only be skilled at detecting single information viability or concentration. This paper presents an inverter-based CMOS ion-sensitive-field-effect-transistor (ISFET) sensor array, featuring bacterial pH detection which is an indicator of viability. The proposed design realizes pH detection using the native passivation layer of CMOS process as a sensing layer and configuring an inverter-based front-end as a capacitive feedback amplifier. This sensor array is assisted by temperature sensing and optical detection which reveals bacterial concentration. The optical detection is enabled using the leakage current of a reset switch as a response to a light source. While in reset mode, the inverter-based amplifier works as a temperature sensor that could help to reduce temperature influences on pH and optical detection. All the functionalities are realized using one single inverter-based amplifier, resulting in a compact pixel structure and largely relaxed design complexity for the sensor system. Fabricated in 0.18
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m standard CMOS process, the proposed CMOS sensor array system achieves an amplified pH sensitivity of 221 mV/pH, an improved sensor resolution of 0.03 pH through systematic noise optimization, a linear optical response, and a maximum temperature error of 0.69
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C. The sensing capabilities of the proposed design are demonstrated through on-chip Escherichia coli (E. coli) detection. This study may be extended to a rapid and cost-effective platform that renders multiple information of bacterial samples. |
Year | DOI | Venue |
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2021 | 10.1109/TBCAS.2021.3084540 | IEEE Transactions on Biomedical Circuits and Systems |
Keywords | DocType | Volume |
Equipment Design,Escherichia coli,Hydrogen-Ion Concentration,Temperature,Transistors, Electronic | Journal | 15 |
Issue | ISSN | Citations |
3 | 1932-4545 | 0 |
PageRank | References | Authors |
0.34 | 0 | 6 |
Name | Order | Citations | PageRank |
---|---|---|---|
Mingzheng Duan | 1 | 0 | 0.34 |
Xiaopeng Zhong | 2 | 17 | 3.21 |
Zhou Xu | 3 | 66 | 15.44 |
Omar El-Agnaf | 4 | 0 | 0.34 |
Yi-Kuen Lee | 5 | 7 | 11.16 |
A. Bermak | 6 | 35 | 4.72 |