Paper Info
Title
Endoscopy-Assisted Magnetic Navigation Of Biohybrid Soft Microrobots With Rapid Endoluminal Delivery And Imaging
Abstract
High-precision delivery of microrobots at the whole-body scale is of considerable importance for efforts toward targeted therapeutic intervention. However, vision-based control of microrobots, to deep and narrow spaces inside the body, remains a challenge. Here, we report a soft and resilient magnetic cell microrobot with high biocompatibility that can interface with the human body and adapt to the complex surroundings while navigating inside the body. We achieve time-efficient delivery of soft microrobots using an integrated platform called endoscopyassisted magnetic actuation with dual imaging system (EMADIS). EMADIS enables rapid deployment across multiple organ/tissue barriers at the whole-body scale and high-precision delivery of soft and biohybrid microrobots in real time to tiny regions with depth up to meter scale through natural orifice, which are commonly inaccessible and even invisible by conventional endoscope and medical robots. The precise delivery of magnetic stem cell spheroid microrobots (MSCSMs) by the EMADIS transesophageal into the bile duct with a total distance of about 100 centimeters can be completed within 8 minutes. The integration strategy offers a full clinical imaging technique? based therapeutic/intervention system, which broadens the accessibility of hitherto hard-to-access regions, by means of soft microrobots.
Year
DOI
Venue
2021
10.1126/scirobotics.abd2813
SCIENCE ROBOTICS
DocType
Volume
Issue
Journal
6
52
ISSN
Citations 
PageRank 
2470-9476
4
0.42
References 
Authors
0
11
Name
Order
Citations
PageRank
Ben Wang111815.13
Kai-Fung Chan260.78
Ke Yuan3293.80
Qianqian Wang413226.59
Xianfeng Xia540.42
Lidong Yang6196.77
Ho Ko740.42
Yi-Xiang J Wang840.42
Joseph Jao Yiu Sung940.42
Philip W. Y. Chiu102410.57
L. Zhang1117127.67