Name
Abstract | ||
|---|---|---|
In this paper we present the design of a new point-of-care device for protein quantification. The proposed design is based on a novel aptamer-mediated methodology and real time polymerase chain reaction (RT-PCR), a robust and ultra-sensitive method for DNA amplification, which we employ for very sensitive quantification of proteins. In addition, we have also developed an algorithm for the processing of raw fluorescence data from the portable RT-PCR device. The algorithm leads to better linearity than a proprietary software from a commercially available RT-PCR machine. The modular nature of the system allows for easy assembly and adjustment towards a variety of biomarkers for applications in disease diagnosis and personalised medicine. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1109/ISCAS51556.2021.9401643 | 2021 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS) |
Keywords | DocType | ISSN |
System design, point-of-care, RT-PCR, algorithm, noise minimisation | Conference | 0271-4302 |
Citations | PageRank | References |
0 | 0.34 | 0 |
Authors | ||
6 | ||
Name | Order | Citations | PageRank |
|---|---|---|---|
| Francesca Romana Cavallo | 1 | 0 | 0.34 |
| Khalid B. Mirza | 2 | 0 | 2.70 |
| Sara de Mateo | 3 | 0 | 1.35 |
| Jesus Rodriguez Manzano | 4 | 0 | 0.34 |
| Konstantin Nikolic | 5 | 26 | 8.09 |
| Christofer Toumazou | 6 | 265 | 59.06 |