Paper Info
Title
The Value Of Heart Rhythm Complexity In Identifying High-Risk Pulmonary Hypertension Patients
Abstract
Pulmonary hypertension (PH) is a fatal disease-even with state-of-the-art medical treatment. Non-invasive clinical tools for risk stratification are still lacking. The aim of this study was to investigate the clinical utility of heart rhythm complexity in risk stratification for PH patients. We prospectively enrolled 54 PH patients, including 20 high-risk patients (group A; defined as WHO functional class IV or class III with severely compromised hemodynamics), and 34 low-risk patients (group B). Both linear and non-linear heart rate variability (HRV) variables, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE), were analyzed. In linear and non-linear HRV analysis, low frequency and high frequency ratio, DFA alpha 1, MSE slope 5, scale 5, and area 6-20 were significantly lower in group A. Among all HRV variables, MSE scale 5 (AUC: 0.758) had the best predictive power to discriminate the two groups. In multivariable analysis, MSE scale 5 (p = 0.010) was the only significantly predictor of severe PH in all HRV variables. In conclusion, the patients with severe PH had worse heart rhythm complexity. MSE parameters, especially scale 5, can help to identify high-risk PH patients.
Year
DOI
Venue
2021
10.3390/e23060753
ENTROPY
Keywords
DocType
Volume
pulmonary hypertension, heart rate variability, non-linear analysis, detrended fluctuation analysis, multiscale entropy
Journal
23
Issue
ISSN
Citations 
6
1099-4300
0
PageRank 
References 
Authors
0.34
0
13
Name
Order
Citations
PageRank
Shu-Yu Tang100.34
Hsi-Pin Ma26818.95
Chi-Sheng Hung321.92
Ping-Hung Kuo400.34
Chen Lin5163.71
Men-Tzung Lo68313.65
Hsao-Hsun Hsu700.34
Yu-Wei Chiu801.01
Cho-Kai Wu900.34
Cheng-Hsuan Tsai1000.34
Yen-Tin Lin1100.34
Chung-Kang Peng12295.02
Yen-hung Lin1311913.81