Paper Info
Title
Dynamic analysis of disease progression in Alzheimer’s disease under the influence of hybrid synapse and spatially correlated noise
Abstract
Alzheimer’s disease (AD), characterized by cognitive impairment, mainly affects middle-aged and elderly people. As the aging process of the world continues to intensify, AD harms people’s life, economy and society more and more seriously. Therefore, it has become an urgent problem to study the pathogenesis of AD and seek treatment on this basis. Hybrid synapse, autapse and spatial correlated noise in diverse neural activities have been investigated separately, however, theoretically understanding combination of them still has not been fully studied. Here in this paper, a neural network with multiple associative memory abilities is established from the perspective of the degeneration of associative memory ability in AD patients under the conditions of hybrid synapse, autapse and spatial correlated noise. In order to explore the pathogenesis, a synaptic loss and synaptic compensation model are established to analyze the associative memory ability of AD in different degrees of disease. The simulation results demonstrate the effectiveness of the proposed models and pave a way in the study of dynamic mechanism with higher bio-interpretability in neural networks.
Year
DOI
Venue
2021
10.1016/j.neucom.2021.05.067
Neurocomputing
Keywords
DocType
Volume
Alzheimer’s disease,Associative memory,Synaptic plasticity,Hybrid synapse,Spatial correlated noise
Journal
456
ISSN
Citations 
PageRank 
0925-2312
0
0.34
References 
Authors
0
10
Name
Order
Citations
PageRank
Wang Weiping133563.84
Chang He200.68
Zhen Wang3106085.86
Jun Cheng411.02
Xishuo Mo500.34
Kuo Tian600.34
Denggui Fan700.34
Xiong Luo89617.06
Manman Yuan9133.55
Jürgen Kurths102000142.58