Name
Title | ||
|---|---|---|
Integrative resource for network-based investigation of COVID-19 combinatorial drug repositioning and mechanism of action |
Abstract | ||
|---|---|---|
An effective monotherapy to target the complex and multifactorial pathology of SARS-CoV-2 infection poses a challenge to drug repositioning, which can be improved by combination therapy. We developed an online network pharmacology-based drug repositioning platform, COVID-CDR (http://vafaeelab.com/COVID19repositioning.html), that enables a visual and quantitative investigation of the interplay between the primary drug targets and the SARS-CoV-2-host interactome in the human protein-protein interaction network. COVID-CDR prioritizes drug combinations with potential to act synergistically through different, yet potentially complementary, pathways. It provides the options for understanding multi-evidence drug-pair similarity scores along with several other relevant information on individual drugs or drug pairs. Overall, COVID-CDR is a first-of-its-kind online platform that provides a systematic approach for pre-clinical in silico investigation of combination therapies for treating COVID-19 at the fingertips of the clinicians and researchers. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1016/j.patter.2021.100325 | PATTERNS |
Keywords | DocType | Volume |
COVID-19,SARS-CoV-2,combination therapies,drug repositioning | Journal | 2 |
Issue | ISSN | Citations |
9 | 2666-3899 | 0 |
PageRank | References | Authors |
0.34 | 0 | 5 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| AKM Azad | 1 | 0 | 0.68 |
| Shadma Fatima | 2 | 0 | 0.34 |
| Alexander Capraro | 3 | 0 | 0.34 |
| Shafagh A Waters | 4 | 0 | 0.34 |
| Fatemeh Vafaee | 5 | 64 | 6.48 |