Name
Title | ||
|---|---|---|
Green Synthesis Of Selenium Based N-Heterocyclic Carbene Compounds; Structural, In-Vitro Anticancer And Molecular Docking Studies |
Abstract | ||
|---|---|---|
Benzimidazolium salts (3-6) were synthesized as stable N-Heterocyclic Carbene (NHC) precursors and their selenium-NHC compounds/Selenones (7-10) were prepared using water as a solvent. Characterization of each of the synthesized compounds was carried out by various analytical and spectroscopic (FT-IR, H-1-, C-13 NMR) methods. X-ray crystallographic analyses of single crystals obtained for salts 3 and 5 were carried out. Synthesized salts and their Se-NHCs were tested in-vitro for their anticancer potential against Cervical Cancer Cell line from Henrietta Lacks (HeLa), Breast cancer cell line (MDA-MB-231), Adenocarcinoma cell line (A549) and human normal endothelial cell line (EA.hy926). MTT assay was used for analysis and compared with standard drug 5-flourouracil. Benzimidazolium salts (3-6) and their selenium counter parts (7-10) were found potent anticancer agents. Salt 3-5 were found to be potent anticancer against HeLa with IC50 values 0.072, 0.017 and 0.241 mu M, respectively, which are less than standard drug (4.9 mu M). The Se-NHCs (7-10) had also shown significant anticancer potential against HeLa with IC50 values less than standard drug. Salts 3, 4 against EA.hy926, compounds 3,5,6, and 10 against MDA-MB-321, and compounds 4, 10 against A-549 cell line were found more potent anticancer agents with IC50 values less than standard drug. Molecular docking for (7-10) showed their good anti-angiogenic potential having low binding energy and significant inhibition constant values with VEGFA (vascular endothelial growth factor), EGF (human epidermal growth factor), COX1 (cyclooxygenase-1) and HIF (hypoxia inducible factor). |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1016/j.compbiolchem.2021.107567 | COMPUTATIONAL BIOLOGY AND CHEMISTRY |
Keywords | DocType | Volume |
Selenium NHCs, Cervical cancer (HeLa), Breast cancer (MDA-MB-231), Adenocarcinoma (A-549), Molecular docking | Journal | 94 |
ISSN | Citations | PageRank |
1476-9271 | 0 | 0.34 |
References | Authors | |
0 | 9 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Khizar Hayat | 1 | 248 | 19.71 |
| Umaira Tariq | 2 | 0 | 0.34 |
| Qin Ai Wong | 3 | 0 | 0.34 |
| Ching Kheng Quah | 4 | 1 | 0.98 |
| Aman Shah Abdul Majid | 5 | 0 | 0.34 |
| Mansoureh Nazari V | 6 | 0 | 0.34 |
| Mohamed B Khadeer Ahamed | 7 | 0 | 0.34 |
| Muhammad Adnan Iqbal | 8 | 0 | 0.34 |
| Syed Ahmed Tirmizi | 9 | 0 | 0.34 |