Title
MASG-GAN: A multi-view attention superpixel-guided generative adversarial network for efficient and simultaneous histopathology image segmentation and classification
Abstract
Efficient analysis of Haematoxylin and Eosin stained histopathology images has become a challenge in digital pathology work-flow. We propose a Multi-view Attention Superpixel-guided Generative Adversarial Network (MASG-GAN) to achieve the multi-task learning for nuclei segmentation and benign-malignant tissue classification. Firstly, a novel superpixel segmentation approach driven by Bounded Asymmetric Gaussian Mixture Model (BAGMM) is presented for generating superpixel-prior probability map with high-level semantics. Then, we develop a generator network that integrates student-branch and teacher-branch. Concretely, the teacher-branch takes superpixel-prior probability map as input and guides the student-branch for accurate segmentation and classification. Then in generator, we build a light-weight U-shaped block (LUB) that consists of depthwise separable convolutions with mini encoding-decoding structure to reduce network computational cost. Finally, a Multi-view Attention Module (MVAM) is designed for further enhance the segmentation quality of nuclei with small area and unclear boundary. Extensive experiments on five benchmark datasets demonstrate that our pipeline outperforms some state-of-the-art methods, especially in terms of efficiency.
Year
DOI
Venue
2021
10.1016/j.neucom.2021.08.039
Neurocomputing
Keywords
DocType
Volume
Histopathology image,Nuclei segmentation,Bounded asymmetric Gaussian mixture model,Superpixel,Generative adversarial network,Multi-view attention
Journal
463
ISSN
Citations 
PageRank 
0925-2312
0
0.34
References 
Authors
0
4
Name
Order
Citations
PageRank
Huaqi Zhang100.34
Jie Liu200.34
Zekuan Yu302.70
Pengyu Wang403.38