Title
Accelerating large scale de novo metagenome assembly using GPUs
Abstract
ABSTRACTMetagenomic workflows involve studying uncultured microorganisms directly from the environment. These environmental samples when processed by modern sequencing machines yield large and complex datasets that exceed the capabilities of metagenomic software. The increasing sizes and complexities of datasets make a strong case for exascale-capable metagenome assemblers. However, the underlying algorithmic motifs are not well suited for GPUs. This poses a challenge since the majority of next-generation supercomputers will rely primarily on GPUs for computation. In this paper we present the first of its kind GPU-accelerated implementation of the local assembly approach that is an integral part of a widely used large-scale metagenome assembler, MetaHipMer. Local assembly uses algorithms that induce random memory accesses and non-deterministic workloads, which make GPU offloading a challenging task. Our GPU implementation outperforms the CPU version by about 7x and boosts the performance of MetaHipMer by 42% when running on 64 Summit nodes.
Year
DOI
Venue
2021
10.1145/3458817.3476212
SC
DocType
Citations 
PageRank 
Conference
0
0.34
References 
Authors
0
8
Name
Order
Citations
PageRank
Muaaz Gul Awan100.34
Steven A. Hofmeyr22096258.76
Rob Egan3494.64
Nan Ding412730.26
Aydin Buluc5105767.49
Jack Deslippe600.68
leonid oliker71358145.15
Katherine A. Yelick83494407.23