Title
Reducing False-Positive Biopsies using Deep Neural Networks that Utilize both Local and Global Image Context of Screening Mammograms
Abstract
Breast cancer is the most common cancer in women, and hundreds of thousands of unnecessary biopsies are done around the world at a tremendous cost. It is crucial to reduce the rate of biopsies that turn out to be benign tissue. In this study, we build deep neural networks (DNNs) to classify biopsied lesions as being either malignant or benign, with the goal of using these networks as second readers serving radiologists to further reduce the number of false-positive findings. We enhance the performance of DNNs that are trained to learn from small image patches by integrating global context provided in the form of saliency maps learned from the entire image into their reasoning, similar to how radiologists consider global context when evaluating areas of interest. Our experiments are conducted on a dataset of 229,426 screening mammography examinations from 141,473 patients. We achieve an AUC of 0.8 on a test set consisting of 464 benign and 136 malignant lesions.
Year
DOI
Venue
2021
10.1007/s10278-021-00530-6
JOURNAL OF DIGITAL IMAGING
Keywords
DocType
Volume
Breast cancer, Deep neural networks, Screening mammography, Global context, Local patterns
Journal
34
Issue
ISSN
Citations 
6
0897-1889
0
PageRank 
References 
Authors
0.34
0
11
Name
Order
Citations
PageRank
Nan Wu1162.66
Zhe Huang23510.87
Yiqiu Shen3162.32
Jungkyu Park400.34
Jason Phang5224.09
Taro Makino600.34
S. Kim7516.55
Kyunghyun Cho86803316.85
Heacock Laura911.04
Linda Moy1042543.60
Krzysztof Geras11757.45