Paper Info
Title
Analyzing T cell receptor alpha/beta usage in binding to the pMHC
Abstract
T cells play a critical role in the adaptive immune response. They perform their function by recognizing infected cells presenting peptides on a specialized complex known as the MHC. The recognition process involves binding of the peptide-loaded MHC to the T cell receptor (TCR), a surface molecule comprised of an alpha and a beta chain. A large body of evidence suggests that T cells can respond to previously unseen pathogens, a phenomenon known as cross-reactivity. Cross-reactivity has important medical implications, as cross-reactive responses can be either protective or lead to disease. A possible mechanism that has been proposed to explain cross-reactivity is the differential usage of the alpha and beta chains, whereas one peptide can be recognized predominantly by the alpha chain and a different peptide by the beta chain. In this study we carry out a systematic analysis of a non-redundant set of 67 crystal structures, measuring TCR alpha/beta usage and its relationship with structural features of the interaction. Our results show a wide range of TCR alpha/beta usage in different complexes. Further, we find that alpha/beta usage significantly correlates with one of the docking angles between the TCR and the MHC.
Year
DOI
Venue
2017
10.1109/BIBM.2017.8217629
2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
Keywords
DocType
ISSN
beta chain,T cells,alpha chain,crystal structures,TCR alpha-beta usage,T cell receptor alpha-beta usage,pMHC,peptide-loaded MHC,disease
Conference
2156-1125
ISBN
Citations 
PageRank 
978-1-5090-3051-4
0
0.34
References 
Authors
0
2
Name
Order
Citations
PageRank
Ryan Ehrlich100.34
Dario Ghersi2667.04