Name
Abstract | ||
|---|---|---|
Cell motility is potentially the most apparent distinction of living matter, serving an essential purpose in single cells and multicellular organisms alike. Thus, the bottom-up reconstitution of autonomous motion of cell-sized compartments remains an exciting but challenging goal. Herein, actin-driven Marangoni flows are engineered to generate rotational and translational motility of surfactant-stabilized emulsion droplets. The interaction between actin filaments and the negatively charged block-copolymer Krytox is identified as the driving force for Marangoni flows at the droplet interface. Tuning the actin-Krytox interplay, sustained autonomous unidirectional droplet rotation with 1.7 rot h(-1) is achieved. Ultimately, this rotational motion is transformed into a translational rolling motion by introducing interactions between the droplets and the surface of the observation chamber. Accordingly, translational motility of actin-containing droplets at velocities of 0.061 +/- 0.014 mu m s(-1) is reported herein and an overall displacement of several hundreds of micrometers within 30 min is observed. These self-propelled systems with biologically active molecules demonstrate how motility could be implemented for synthetic cells. |
Year | DOI | Venue |
|---|---|---|
2021 | 10.1002/aisy.202000190 | ADVANCED INTELLIGENT SYSTEMS |
Keywords | DocType | Volume |
actin, droplet-based microfluidics, Marangoni effect, motility, surfactants, synthetic biology | Journal | 3 |
Issue | Citations | PageRank |
5 | 0 | 0.34 |
References | Authors | |
0 | 6 | |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Barbara Haller | 1 | 0 | 0.34 |
| Kevin Jahnke | 2 | 0 | 0.34 |
| Marian Weiss | 3 | 0 | 0.34 |
| Kerstin Goepfrich | 4 | 0 | 0.34 |
| Ilia Platzman | 5 | 0 | 0.34 |
| Joachim Pius Spatz | 6 | 0 | 0.34 |