Title
Diagnose Like a Radiologist: Hybrid Neuro-Probabilistic Reasoning for Attribute-Based Medical Image Diagnosis
Abstract
During clinical practice, radiologists often use attributes, e.g., morphological and appearance characteristics of a lesion, to aid disease diagnosis. Effectively modeling attributes as well as all relationships involving attributes could boost the generalization ability and verifiability of medical image diagnosis algorithms. In this paper, we introduce a hybrid neuro-probabilistic reasoning algorithm for verifiable attribute-based medical image diagnosis. There are two parallel branches in our hybrid algorithm, a Bayesian network branch performing probabilistic causal relationship reasoning and a graph convolutional network branch performing more generic relational modeling and reasoning using a feature representation. Tight coupling between these two branches is achieved via a cross-network attention mechanism and the fusion of their classification results. We have successfully applied our hybrid reasoning algorithm to two challenging medical image diagnosis tasks. On the LIDC-IDRI benchmark dataset for benign-malignant classification of pulmonary nodules in CT images, our method achieves a new state-of-the-art accuracy of 95.36% and an AUC of 96.54%. Our method also achieves a 3.24% accuracy improvement on an in-house chest X-ray image dataset for tuberculosis diagnosis. Our ablation study indicates that our hybrid algorithm achieves a much better generalization performance than a pure neural network architecture under very limited training data.
Year
DOI
Venue
2022
10.1109/TPAMI.2021.3130759
IEEE Transactions on Pattern Analysis and Machine Intelligence
Keywords
DocType
Volume
Bayesian networks,deep neural networks,medical image analysis,neuro-probabilistic reasoning
Journal
44
Issue
ISSN
Citations 
11
0162-8828
1
PageRank 
References 
Authors
0.36
19
5
Name
Order
Citations
PageRank
Gangming Zhao193.88
Quanlong Feng210.36
Chaoqi Chen310.36
Zhen Zhou43012.87
Yizhou Yu52907181.26