Paper Info
Title
Dissecting cascade computational components in spiking neural networks
Abstract
Finding out the physical structure of neuronal circuits that governs neuronal responses is an important goal for brain research. With fast advances for large-scale recording techniques, identification of a neuronal circuit with multiple neurons and stages or layers becomes possible and highly demanding. Although methods for mapping the connection structure of circuits have been greatly developed in recent years, they are mostly limited to simple scenarios of a few neurons in a pairwise fashion; and dissecting dynamical circuits, particularly mapping out a complete functional circuit that converges to a single neuron, is still a challenging question. Here, we show that a recent method, termed spike-triggered non-negative matrix factorization (STNMF), can address these issues. By simulating different scenarios of spiking neural networks with various connections between neurons and stages, we demonstrate that STNMF is a persuasive method to dissect functional connections within a circuit. Using spiking activities recorded at neurons of the output layer, STNMF can obtain a complete circuit consisting of all cascade computational components of presynaptic neurons, as well as their spiking activities. For simulated simple and complex cells of the primary visual cortex, STNMF allows us to dissect the pathway of visual computation. Taken together, these results suggest that STNMF could provide a useful approach for investigating neuronal systems leveraging recorded functional neuronal activity. Author summaryIt is well known that the computation of neuronal circuits is carried out through the staged and cascade structure of different types of neurons. Nevertheless, the information, particularly sensory information, is processed in a network primarily with feedforward connections through different pathways. A peculiar example is the early visual system, where light is transcoded by the retinal cells, routed by the lateral geniculate nucleus, and reached the primary visual cortex. One meticulous interest in recent years is to map out these physical structures of neuronal pathways. However, most methods so far are limited to taking snapshots of a static view of connections between neurons. It remains unclear how to obtain a functional and dynamical neuronal circuit beyond the simple scenarios of a few randomly sampled neurons. Using simulated spiking neural networks of visual pathways with different scenarios of multiple stages, mixed cell types, and natural image stimuli, we demonstrate that a recent computational tool, named spike-triggered non-negative matrix factorization, can resolve these issues. It enables us to recover the entire structural components of neural networks underlying the computation, together with the functional components of each individual neuron. Utilizing it for complex cells of the primary visual cortex allows us to reveal every underpinning of the nonlinear computation. Our results, together with other recent experimental and computational efforts, show that it is possible to systematically dissect neural circuitry with detailed structural and functional components.
Year
DOI
Venue
2021
10.1371/journal.pcbi.1009640
PLOS COMPUTATIONAL BIOLOGY
DocType
Volume
Issue
Journal
17
11
ISSN
Citations 
PageRank 
1553-734X
0
0.34
References 
Authors
0
4
Name
Order
Citations
PageRank
Shanshan Jia132.29
Dajun Xing231.07
Zhaofei Yu33816.83
Jian K. Liu4208.77