Title
Content-based image retrieval with a Convolutional Siamese Neural Network: Distinguishing lung cancer and tuberculosis in CT images
Abstract
Background: CT findings of lung cancer and tuberculosis are sometimes similar, potentially leading to misdiag-nosis. This study aims to combine deep learning and content-based image retrieval (CBIR) to distinguish lung cancer (LC) from nodular/mass atypical tuberculosis (NMTB) in CT images. Methods: This study proposes CBIR with a convolutional Siamese neural network (CBIR-CSNN). First, the lesion patches are cropped out to compose LC and NMTB datasets and the pairs of two arbitrary patches form a patch-pair dataset. Second, this patch-pair dataset is utilized to train a CSNN. Third, a test patch is treated as a query. The distance between this query and 20 patches in both datasets is calculated using the trained CSNN. The patches closest to the query are used to give the final prediction by majority voting. One dataset of 719 patients is used to train and test the CBIR-CSNN. Another external dataset with 30 patients is employed to verify CBIR-CSNN. Results: The CBIR-CSNN achieves excellent performance at the patch level with an mAP (Mean Average Preci-sion) of 0.953, an accuracy of 0.947, and an area under the curve (AUC) of 0.970. At the patient level, the CBIR-CSNN correctly predicted all labels. In the external dataset, the CBIR-CSNN has an accuracy of 0.802 and AUC of 0.858 at the patch level, and 0.833 and 0.902 at the patient level. Conclusions: This CBIR-CSNN can accurately and automatically distinguish LC from NMTB using CT images. CBIR-CSNN has excellent representation capability, compatibility with few-shot learning, and visual explainability.
Year
DOI
Venue
2022
10.1016/j.compbiomed.2021.105096
COMPUTERS IN BIOLOGY AND MEDICINE
Keywords
DocType
Volume
Content-based imaging retrieval, Siamese network, Lung cancer, Nodular, mass atypical pulmonary tuberculosis
Journal
140
ISSN
Citations 
PageRank 
0010-4825
0
0.34
References 
Authors
0
8
Name
Order
Citations
PageRank
Kai Zhang100.34
Shouliang Qi203.04
Jiumei Cai300.34
Dan Zhao400.34
Tao Yu500.34
Yong Yue600.34
Yu-Dong Yao71781119.83
Wei Qian843.19