Title
Pre-implant Heart Activity Differs in Responders and Non-responders to Vagal Nerve Stimulation Therapy in Epileptic Patients
Abstract
Vagal Nerve Stimulation (VNS) is used to treat patients with pharmacoresistant epilepsy. However, generally accepted tools to predict VNS response do not exist. Here we examined two heart activity measures - mean RR and pNN50 and their complex behavior during activation in pre-implant measurements. The ECG recordings of 73 patients (38 responders, 36 non-responders) were examined in a 30-sec floating window before (120 sec), during (2x120 sec), and after (120 sec) the hyperventilation by nose and mouth. The VNS response differentiation by pNN50 was significant (min p=0.01) in the hyperventilation by a nose with a noticeable descendant trend in nominal values. The mean RR was significant (p=0.01) in the rest after the hyperventilation by mouth but after an approximately 40-sec delay.
Year
DOI
Venue
2021
10.1109/EMBC46164.2021.9629577
2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)
DocType
Volume
ISSN
Conference
2021
1557-170X
Citations 
PageRank 
References 
0
0.34
0
Authors
10
Name
Order
Citations
PageRank
F Plesinger100.34
J Halamek200.34
J Chladek300.34
P Jurak400.34
A Ivora500.34
I Dolezalova600.34
E Koritakova700.34
T Jurkova800.34
J Chrastina900.34
M Brazdil1000.34