Title
Domain generalization on medical imaging classification using episodic training with task augmentation
Abstract
Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which aims to learn a model from multiple source domains such that it can be directly generalized to unseen test domains, seems particularly promising to medical imaging community. To address DG, recent model-agnostic meta-learning (MAML) has been introduced, which transfers the knowledge from previous training tasks to facilitate the learning of novel testing tasks. However, in clinical practice, there are usually only a few annotated source domains available, which decreases the capacity of training task generation and thus increases the risk of overfitting to training tasks in the paradigm. In this paper, we propose a novel DG scheme of episodic training with task augmentation on medical imaging classification. Based on meta-learning, we develop the paradigm of episodic training to construct the knowledge transfer from episodic training-task simulation to the real testing task of DG. Motivated by the limited number of source domains in real-world medical deployment, we consider the unique task-level overfitting and we propose task augmentation to enhance the variety during training task generation to alleviate it. With the established learning framework, we further exploit a novel meta-objective to regularize the deep embedding of training domains. To validate the effectiveness of the proposed method, we perform experiments on histopathological images and abdominal CT images.
Year
DOI
Venue
2022
10.1016/j.compbiomed.2021.105144
COMPUTERS IN BIOLOGY AND MEDICINE
Keywords
DocType
Volume
Medical imaging classification, Domain generalization, Model-agnostic meta-learning, Episodic training, Task-level overfitting
Journal
141
ISSN
Citations 
PageRank 
0010-4825
0
0.34
References 
Authors
0
9
Name
Order
Citations
PageRank
Chenxin Li132.07
Xin Lin200.34
Yijin Mao300.34
Wei Lin400.34
Qi Qi511.36
Xinghao Ding600.68
Yue Huang701.35
Dong Liang800.34
Yizhou Yu92907181.26