Title
Improving Medical Images Classification With Label Noise Using Dual-Uncertainty Estimation
Abstract
Deep neural networks are known to be data-driven and label noise can have a marked impact on model performance. Recent studies have shown great robustness to classic image recognition even under a high noisy rate. In medical applications, learning from datasets with label noise is more challenging since medical imaging datasets tend to have instance-dependent noise (IDN) and suffer from high observer variability. In this paper, we systematically discuss the two common types of label noise in medical images - disagreement label noise from inconsistency expert opinions and single-target label noise from biased aggregation of individual annotations. We then propose an uncertainty estimation-based framework to handle these two label noise amid the medical image classification task. We design a dual-uncertainty estimation approach to measure the <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">disagreement label noise</b> and <bold xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">single-target label noise</b> via improved Direct Uncertainty Prediction and Monte-Carlo-Dropout. A boosting-based curriculum training procedure is later introduced for robust learning. We demonstrate the effectiveness of our method by conducting extensive experiments on three different diseases with synthesized and real-world label noise: skin lesions, prostate cancer, and retinal diseases. We also release a large re-engineered database that consists of annotations from more than ten ophthalmologists with an unbiased golden standard dataset for evaluation and benchmarking. The dataset is available at <uri xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">https://mmai.group/peoples/julie/</uri> .
Year
DOI
Venue
2022
10.1109/TMI.2022.3141425
IEEE Transactions on Medical Imaging
Keywords
DocType
Volume
Diagnostic Imaging,Neural Networks, Computer,Noise,Radiography,Uncertainty
Journal
41
Issue
ISSN
Citations 
6
0278-0062
0
PageRank 
References 
Authors
0.34
11
8
Name
Order
Citations
PageRank
Lie Ju110.69
Xin Wang201.35
Lin Wang322.41
Dwarikanath Mahapatra431233.71
Xin Zhao522.07
Quan Zhou600.34
Tongliang Liu790247.13
zongyuan ge814927.83