Paper Info
Title
MonaGO: a novel gene ontology enrichment analysis visualisation system
Abstract
Background Gene ontology (GO) enrichment analysis is frequently undertaken during exploration of various -omics data sets. Despite the wide array of tools available to biologists to perform this analysis, meaningful visualisation of the overrepresented GO in a manner which is easy to interpret is still lacking. Results Monash Gene Ontology (MonaGO) is a novel web-based visualisation system that provides an intuitive, interactive and responsive interface for performing GO enrichment analysis and visualising the results. MonaGO supports gene lists as well as GO terms as inputs. Visualisation results can be exported as high-resolution images or restored in new sessions, allowing reproducibility of the analysis. An extensive comparison between MonaGO and 11 state-of-the-art GO enrichment visualisation tools based on 9 features revealed that MonaGO is a unique platform that simultaneously allows interactive visualisation within one single output page, directly accessible through a web browser with customisable display options. Conclusion MonaGO combines dynamic clustering and interactive visualisation as well as customisation options to assist biologists in obtaining meaningful representation of overrepresented GO terms, producing simplified outputs in an unbiased manner. MonaGO will facilitate the interpretation of GO analysis and will assist the biologists into the representation of the results.
Year
DOI
Venue
2022
10.1186/s12859-022-04594-1
BMC BIOINFORMATICS
Keywords
DocType
Volume
Gene ontology, GO enrichment, Web services, Interactive visualisation, Semantic web
Journal
23
Issue
ISSN
Citations 
1
1471-2105
0
PageRank 
References 
Authors
0.34
0
10
Name
Order
Citations
PageRank
Ziyin Xin100.34
Yujun Cai200.34
Louis T Dang300.34
Hannah M S Burke400.34
Jerico Revote551.47
Natalie Charitakis600.34
Denis Bienroth700.34
Hieu T Nim800.34
Yuan-Fang Li924539.15
Mirana Ramialison1000.34