Paper Info
Title
Anti-CRISPRdb v2.2: an online repository of anti-CRISPR proteins including information on inhibitory mechanisms, activities and neighbors of curated anti-CRISPR proteins
Abstract
We previously released the Anti-CRISPRdb database hosting anti-CRISPR proteins (Acrs) and associated information. Since then, the number of known Acr families, types, structures and inhibitory activities has accumulated over time, and Acr neighbors can be used as a candidate pool for screening Acrs in further studies. Therefore, we here updated the database to include the new available information. Our newly updated database shows several improvements: (i) it comprises more entries and families because it includes both Acrs reported in the most recent literatures and Acrs obtained via performing homologous alignment; (ii) the prediction of Acr neighbors is integrated into Anti-CRISPRdb v2.2, and users can identify novel Acrs from these candidates; and (iii) this version includes experimental information on the inhibitory strength and stage for Acr-Cas/Acr-CRISPR pairs, motivating the development of tools for predicting specific inhibitory abilities. Additionally, a parameter, the rank of codon usage bias (CUBRank), was proposed and provided in the new version, which showed a positive relationship with predicted result from AcRanker; hence, it can be used as an indicator for proteins to be Acrs. CUBRank can be used to estimate the possibility of genes occurring within genome island?a hotspot hosting potential genes encoding Acrs. Based on CUBRank and Anti-CRISPRdb, we also gave the first glimpse for the emergence of Acr genes (acrs).
Year
DOI
Venue
2022
10.1093/database/baac010
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
DocType
Volume
ISSN
Journal
2022
1758-0463
Citations 
PageRank 
References 
0
0.34
0
Authors
10
Name
Order
Citations
PageRank
Chuan Dong100.34
Xin Wang2018.25
Cong Ma300.34
Zhi Zeng400.34
Dong-Kai Pu500.34
Shuo Liu671.15
Candy-S Wu700.34
Shixin Chen800.34
Zixin Deng9395.74
Feng-Biao Guo1000.34