Title
Automated Registration for Dual-View X-Ray Mammography Using Convolutional Neural Networks
Abstract
<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Objective:</i> Automated registration algorithms for a pair of 2D X-ray mammographic images taken from two standard imaging angles, namely, the craniocaudal (CC) and the mediolateral oblique (MLO) views, are developed. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Methods:</i> A fully convolutional neural network, a type of convolutional neural network (CNN), is employed to generate a pixel-level deformation field, which provides a mapping between masses in the two views. Novel distance-based regularization is employed, which contributes significantly to the performance. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Results:</i> The developed techniques are tested using real 2D mammographic images, slices from real 3D mammographic images, and synthetic mammographic images. Architectural variations of the neural network are investigated and the performance is characterized from various aspects including image resolution, breast density, lesion size, lesion subtlety, and lesion Breast Imaging-Reporting and Data System (BI-RADS) category. Our network outperformed the state-of-the-art CNN-based and non-CNN-based registration techniques, and showed robust performance across various tissue/lesion characteristics. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Conclusion:</i> The proposed methods provide a useful automated tool for co-locating lesions between the CC and MLO views even in challenging cases. <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Significance:</i> Our methods can aid clinicians to establish lesion correspondence quickly and accurately in the dual-view X-ray mammography, improving diagnostic capability.
Year
DOI
Venue
2022
10.1109/TBME.2022.3173182
IEEE Transactions on Biomedical Engineering
Keywords
DocType
Volume
X-Rays,Mammography,Neural Networks, Computer,Algorithms
Journal
69
Issue
ISSN
Citations 
11
0018-9294
0
PageRank 
References 
Authors
0.34
27
3
Name
Order
Citations
PageRank
William C Walton100.34
Seung-Jun Kim2100362.52
Lisa A Mullen300.34