Title
Smart imaging to empower brain-wide neuroscience at single-cell levels
Abstract
A deep understanding of the neuronal connectivity and networks with detailed cell typing across brain regions is necessary to unravel the mechanisms behind the emotional and memorial functions as well as to find the treatment of brain impairment. Brain-wide imaging with single-cell resolution provides unique advantages to access morphological features of a neuron and to investigate the connectivity of neuron networks, which has led to exciting discoveries over the past years based on animal models, such as rodents. Nonetheless, high-throughput systems are in urgent demand to support studies of neural morphologies at larger scale and more detailed level, as well as to enable research on non-human primates (NHP) and human brains. The advances in artificial intelligence (AI) and computational resources bring great opportunity to ‘smart’ imaging systems, i.e., to automate, speed up, optimize and upgrade the imaging systems with AI and computational strategies. In this light, we review the important computational techniques that can support smart systems in brain-wide imaging at single-cell resolution.
Year
DOI
Venue
2022
10.1186/s40708-022-00158-4
Brain Informatics
Keywords
DocType
Volume
Smart imaging, Neuroscience, Artificial intelligence, Brain-wide, Single-cell
Journal
9
Issue
ISSN
Citations 
1
2198-4018
0
PageRank 
References 
Authors
0.34
41
10
Name
Order
Citations
PageRank
Shuxia Guo100.34
Jie Xue200.34
Jian Liu300.34
Xiangqiao Ye400.34
Yichen Guo500.34
Di Liu600.34
Xuan Zhao700.34
Feng Xiong800.34
Xiaofeng Han900.34
Hanchuan Peng103930182.27