Title
Detecting Lower MMSE Scores in Older Adults Using Cross-Trial Features From a Dual-Task With Gait and Arithmetic
Abstract
The Mini-Mental State Examination (MMSE) is widely used in clinics to screen for low cognitive status. However, it is limited in that it requires examiners to be present; and has fixed questions that constrain its repeated use. Thus, the MMSE cannot be used as a daily assessment to facilitate early detection of cognitive impairment. To address this issue, we developed an automated system to detect older adults with lower MMSE scores by analyzing performance during a dual task involving stepping and calculation, which can be used repeatedly because its questions were randomly created. Leveraging this advantage, this paper proposes a learning-based method to detect subjects with lower MMSE scores using multiple trials with the dual-task system. We investigated various patterns for effectively combining the features acquired during multiple continuous trials, and analyzed the sensitivity of the number N of trials on detection performance to find the optimal N via experiments. We compared our approach with previous methods and demonstrated the superiority of our strategy. Using the cross-trial feature, our approach achieved an overall performance (sensitivity + specificity) as high as 1.79 for detecting older adults whose MMSE score is equal to or less than 23 (indicate a relatively high probability of dementia), and 1.75 for detecting older adults whose MMSE score is equal to or less than 27 (indicative of a relatively high probability of mild cognitive impairment (MCI)).
Year
DOI
Venue
2021
10.1109/ACCESS.2021.3126067
IEEE ACCESS
Keywords
DocType
Volume
Task analysis, Feature extraction, Dementia, Arithmetic, Standards, Sensitivity, Monitoring, Cognitive impairment, dementia, dual-task, machine learning, MCI, MMSE
Journal
9
ISSN
Citations 
PageRank 
2169-3536
0
0.34
References 
Authors
0
8
Name
Order
Citations
PageRank
Shuqiong Wu100.34
Taku Matsuura200.34
Fumio Okura300.34
Yasushi Makihara4101270.67
Chengju Zhou500.34
Kota Aoki600.34
Ikuhisa Mitsugami74211.97
Yasushi Yagi81752186.22