Paper Info
Title
A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness
Abstract
The measurement of biological tissues' dielectric properties plays a crucial role in determining the state of health, and recent studies have reported microwave biosensing to be an innovative method with great potential in this field. Research has been conducted from the tissue level to the cellular level but, to date, cellular adhesion has never been considered. In addition, conventional systems for diagnosing tumor aggressiveness, such as a biopsy, are rather expensive and invasive. Here, we propose a novel microwave approach for biosensing adherent cancer cells with different malignancy degrees. A circular patch resonator was designed adjusting its structure to a standard Petri dish and a network analyzer was employed. Then, the resonator was realized and used to test two groups of different cancer cell lines, based on various tumor types and aggressiveness: low- and high-aggressive osteosarcoma cell lines (SaOS-2 and 143B, respectively), and low- and high-aggressive breast cancer cell lines (MCF-7 and MDA-MB-231, respectively). The experimental results showed that the sensitivity of the sensor was high, in particular when measuring the resonant frequency. Finally, the sensor showed a good ability to distinguish low-metastatic and high-metastatic cells, paving the way to the development of more complex measurement systems for noninvasive tissue diagnosis.
Year
DOI
Venue
2022
10.3390/s22124383
SENSORS
Keywords
DocType
Volume
measurement of dielectric properties, biosensor, microwaves, noninvasive measurements, cancer cell lines, cancer aggressiveness, osteosarcoma, breast cancer
Journal
22
Issue
ISSN
Citations 
12
1424-8220
0
PageRank 
References 
Authors
0.34
0
7
Name
Order
Citations
PageRank
Livio D'Alvia100.68
Serena Carraro200.34
Barbara Peruzzi300.34
Enrica Urciuoli400.34
Luigi Palla500.34
Zaccaria Del Prete6910.45
Emanuele Rizzuto700.34