Paper Info
Title
Single-Molecule Surface-Enhanced Raman Spectroscopy
Abstract
Single-molecule surface-enhanced Raman spectroscopy (SM-SERS) has the potential to detect single molecules in a non-invasive, label-free manner with high-throughput. SM-SERS can detect chemical information of single molecules without statistical averaging and has wide application in chemical analysis, nanoelectronics, biochemical sensing, etc. Recently, a series of unprecedented advances have been realized in science and application by SM-SERS, which has attracted the interest of various fields. In this review, we first elucidate the key concepts of SM-SERS, including enhancement factor (EF), spectral fluctuation, and experimental evidence of single-molecule events. Next, we systematically discuss advanced implementations of SM-SERS, including substrates with ultra-high EF and reproducibility, strategies to improve the probability of molecules being localized in hotspots, and nonmetallic and hybrid substrates. Then, several examples for the application of SM-SERS are proposed, including catalysis, nanoelectronics, and sensing. Finally, we summarize the challenges and future of SM-SERS. We hope this literature review will inspire the interest of researchers in more fields.
Year
DOI
Venue
2022
10.3390/s22134889
SENSORS
Keywords
DocType
Volume
surface-enhanced Raman spectroscopy, single-molecule detection, surface plasmon resonance, nanoparticle
Journal
22
Issue
ISSN
Citations 
13
1424-8220
0
PageRank 
References 
Authors
0.34
0
4
Name
Order
Citations
PageRank
Yuxuan Qiu100.34
Cuifang Kuang200.34
X.L. Liu31111.83
longhua tang410.77