Title | ||
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Deviation From Model of Normal Aging in Alzheimer's Disease: Application of Deep Learning to Structural MRI Data and Cognitive Tests |
Abstract | ||
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Background. Psychophysiological and cognitive tests as well as other functional studies can detect pre-symptomatic stages of dementia. When assembled with structural data, cognitive tests diagnose NDs more reliably thus becoming a multimodal diagnostic tool. Objective. Our main goal is to improve screening for dementia by studying an association between the brain structure and its function. Hypothetically, the brain structure-function association has features specific for either disease-related cognitive deterioration or normal neurocognitive slowing while aging. Materials and methods. We studied a total number of 287 cognitively normal cases, 646 of mild cognitive impairment, and 369 of Alzheimer's disease. To work out a new marker of neurodegeneration, we created a convolutional neural network-based regression model and predicted the cognitive status of the cognitively preserved examinee from the brain MRI data. This was a model of normal aging. A big deviation from the model suggests a high risk of accelerated cognitive decline. Results. The deviation from the model of normal aging can accurately distinguish cognitively normal subjects from MCI patients (AUC = 0.9957). We also achieved creditable performance in the MCI-versus-AD classification (AUC = 0.9793). We identified a considerable difference in the MMSE test between A-positive and A-negative demented individuals according to ATN-criteria (6.27 +/- 1.82 vs 5.32 +/- 1.9; p < 0.05). Conclusion. The deviation from the model of normal aging can be potentially used as a marker of dementia and as a tool for differentiating Alzheimer's disease from non-Alzheimer's dementia. To find and justify a reliable threshold levels, further research is required. |
Year | DOI | Venue |
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2022 | 10.1109/ACCESS.2022.3174601 | IEEE ACCESS |
Keywords | DocType | Volume |
Error of cognitive score prediction, biomarker, Alzheimer's disease, neuroimaging, convolutional neural network, deep learning, cognitive decline, dementia, aging | Journal | 10 |
ISSN | Citations | PageRank |
2169-3536 | 0 | 0.34 |
References | Authors | |
0 | 4 |
Name | Order | Citations | PageRank |
---|---|---|---|
Tetiana Habuza | 1 | 0 | 0.34 |
Nazar Zaki | 2 | 139 | 14.31 |
Elfadil A. Mohamed | 3 | 0 | 0.34 |
Yauhen Statsenko | 4 | 0 | 0.34 |