Title
Two-stage hybrid network for segmentation of COVID-19 pneumonia lesions in CT images: a multicenter study
Abstract
COVID-19 has been spreading continuously since its outbreak, and the detection of its manifestations in the lung via chest computed tomography (CT) imaging is essential to investigate the diagnosis and prognosis of COVID-19 as an indispensable step. Automatic and accurate segmentation of infected lesions is highly required for fast and accurate diagnosis and further assessment of COVID-19 pneumonia. However, the two-dimensional methods generally neglect the intraslice context, while the three-dimensional methods usually have high GPU memory consumption and calculation cost. To address these limitations, we propose a two-stage hybrid UNet to automatically segment infected regions, which is evaluated on the multicenter data obtained from seven hospitals. Moreover, we train a 3D-ResNet for COVID-19 pneumonia screening. In segmentation tasks, the Dice coefficient reaches 97.23% for lung segmentation and 84.58% for lesion segmentation. In classification tasks, our model can identify COVID-19 pneumonia with an area under the receiver-operating characteristic curve value of 0.92, an accuracy of 92.44%, a sensitivity of 93.94%, and a specificity of 92.45%. In comparison with other state-of-the-art methods, the proposed approach could be implemented as an efficient assisting tool for radiologists in COVID-19 diagnosis from CT images.
Year
DOI
Venue
2022
10.1007/s11517-022-02619-8
Medical & Biological Engineering & Computing
Keywords
DocType
Volume
COVID-19, Infected lesion segmentation, Screening, Computed tomography
Journal
60
Issue
ISSN
Citations 
9
0140-0118
0
PageRank 
References 
Authors
0.34
11
19
Name
Order
Citations
PageRank
Yaxin Shang100.34
Zechen Wei200.34
Hui Hui300.34
Li Chen4532.61
Li Chen5532.61
Li Chen6532.61
Li Chen7532.61
Liang Li8285.33
Yong-Qiang Yu900.68
Ligong Lu1001.69
Qi Yang11324.73
Meiyun Wang1283.55
Meixiao Zhan1300.34
Wei Wang1423441.10
Guanghao Zhang1500.34
Xiangjun Wu1600.34
Jie Liu1719922.56
Jie Tian181475159.24
Yunfei Zha19262.40