Name
Title | ||
|---|---|---|
Non-Invasive Glucose Metabolism Quantification Method Based on Unilateral ICA Image Derived Input Function by Hybrid PET/MR in Ischemic Cerebrovascular Disease |
Abstract | ||
|---|---|---|
The non-invasive quantification of the cerebral metabolic rate for glucose (CMRGlc) and the characterization of cerebral metabolism in the cerebrovascular territories are helpful in understanding ischemic cerebrovascular disease (ICVD). Firstly, we investigated a non-invasive quantification approach based on an image-derived input function (IDIF) in ICVD. Second, we studied the metabolic changes in CMRGlc after surgical intervention. We evaluated the hypothesis that the IDIF method based on the unilateral internal carotid artery could address challenges in ICVD quantification. The CMRGlc and standardized uptake value ratio (SUVR) were used to measure glucose metabolism activity. Healthy controls showed no significant differences in CMRGlc values between bilateral and unilateral IDIF measurements (intraclass correlation coefficient [ICC]: 0.91–0.98). Patients with ICVD showed significantly increased CMRGlc values after surgical intervention for all territories (percentage changes: 7.4%–22.5%). In contrast, SUVR showed minor differences between postoperative and preoperative patients, indicating that it was a poor biomarker for the diagnosis of ICVD. A significant association between CMRGlc and the National Institutes of Health Stroke Scale (NIHSS) scores was observed (
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=-0.54). Our findings suggested that IDIF could be a valuable tool for CMRGlc quantification in patients with ICVD and may advance personalized precision interventions. |
Year | DOI | Venue |
|---|---|---|
2022 | 10.1109/JBHI.2022.3193190 | IEEE Journal of Biomedical and Health Informatics |
Keywords | DocType | Volume |
Glucose metabolism,ischemic cerebrovascular disease,noninvasive quantification,PET/MR,vascular territory | Journal | 26 |
Issue | ISSN | Citations |
10 | 2168-2194 | 0 |
PageRank | References | Authors |
0.34 | 3 | 13 |
Name | Order | Citations | PageRank |
|---|---|---|---|
| Min Wang | 1 | 76 | 27.77 |
| Bixiao Cui | 2 | 0 | 0.34 |
| Yi Shan | 3 | 0 | 0.34 |
| Hongwei Yang | 4 | 0 | 0.34 |
| Zhuang-zhi Yan | 5 | 14 | 8.28 |
| Lalith Kumar Shiyam Sundar | 6 | 0 | 0.34 |
| Ian Alberts | 7 | 0 | 0.34 |
| Axel Rominger | 8 | 0 | 0.34 |
| Thomas Wendler | 9 | 0 | 0.34 |
| Kuangyu Shi | 10 | 36 | 8.12 |
| Yan Ma | 11 | 437 | 76.23 |
| Jiehui Jiang | 12 | 0 | 0.34 |
| Jie Lu | 13 | 51 | 6.19 |